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    • 专利摘要:
    The present invention relates to a device and a method for treating fat cells taken from a patient and intended for transplantation. More specifically, it is a device and a method of aspiration for separating viable fat cells residues and elements that are not graftable. It is an adipose tissue treatment device (G) connected to a suction means (M), consisting of a sealed treatment chamber (A) comprising connecting means (17) to said means for aspiration (M), input means (13) of said adipose tissue before treatment, filter means (3) and at least one outlet means (20) of said adipose tissue (G) after treatment, said filtering means ( 3) comprising a tapered outer wall (31, 31 ') having a constricted base (55) fixed on a helix (25) and an inner sieve means (30) connected to the output means (20), said propeller ( 25) being subjected to the air depression created by the suction means (M) and constituting a rotating mechanical actuating means of said filter means (3).
    公开号:FR3056405A1
    申请号:FR1770365
    申请日:2017-04-11
    公开日:2018-03-30
    发明作者:Najib Taizou
    申请人:Najib Taizou；
    IPC主号:
    专利说明:

    ® FRENCH REPUBLIC
    NATIONAL INSTITUTE OF INDUSTRIAL PROPERTY © Publication number: 3,056,405 (to be used only for reproduction orders)
    ©) National registration number: 17 70 365
    COURBEVOIE © Int Cl 8 : A 61 M 1/00 (2017.01), A 61 M 5/00, B 04 B 3/00
    A1 PATENT APPLICATION
    ©) Date of filing: 11.04.17.(© Priority: © Applicant (s): TAIZOU NAJIB —RR. @ Inventor (s): TAIZOU NAJIB. ©) Date of public availability of the request: 30.03.18 Bulletin 18/13. ©) List of documents cited in the preliminary search report: See the end of this booklet (© References to other related national documents: ® Holder (s): TAIZOU NAJIB. ©) Extension request (s): © Agent (s): TAIZOU NAJIB.
    GREASES
    TAKEN FROM A PATIENT AND
    FR 3 056 405 - A1 (04) DEVICE FOR TREATING CELLS INTENDED FOR A GRAFT.
    The present invention relates to a device and a method for treating fat cells taken from a patient and intended for a transplant. More specifically, it is a device and a suction process for separating viable fat cells from residues and elements which are not graftable.
    It is an adipose tissue treatment device (G) connected to a suction means (M), consisting of a sealed treatment chamber (A) comprising a connection means (17) to said means. suction (M), an inlet means (13) of said adipose tissues before treatment, a filtration means (3) and at least one outlet means (20) of said adipose tissues (G) after treatment, said filtration means ( 3) comprising an outer wall of conical shape (31, 31 ′) comprising a constricted base (55) fixed on a propeller (25) and an internal screening means (30) connected to the outlet means (20), said propeller ( 25) being subjected to the air vacuum created by the suction means (M) and constituting a rotary mechanical actuation means of said filtration means (3).

    -1 DEVICE FOR TREATING FAT CELLS TAKEN FROM A PATIENT AND INTENDED FOR A GRAFT.
    Field of the invention
    The present invention relates to a device and a method for treating fat cells taken from a patient and intended for a transplant. More specifically, it is a device and an aspiration process for separating viable fat cells from residues and elements that are not graftable.
    Brief description of the prior art
    Lipofilling or autograft of fatty tissues is a technique which consists in taking small quantities of fat from a patient to reinject them on the same patient in order to fill or reshape a part of the body.
    After the initial removal of the fat, it should be cleaned in order to separate the intact fat cells from other substances which are not graftable (blood, oil from the explosion of poor quality cells, ...).
    To carry out this cleaning operation, various devices have been developed.
    The product sold under the Puregraft brand consists of a flexible bag comprising a central filter membrane separating two zones. The pocket has a fluid inlet from a patient's body and a fluid outlet for use in another surgical procedure. The collected fat is filtered through the filtration membrane, the poor quality fat and the residues are isolated and removed. The use of this device is however relatively long and ultimately unprofitable.
    The product marketed under the Revolve brand by the company Lifecell allows the fat to be collected, processed and extracted in a single tank. A system allows syringes to be loaded for reinjection directly from the reservoir. The device works by means of a handle which must be activated by rotation after adding a rinsing solution. But this action requires human intervention and therefore monopolizes staff.
    The patent US2008 / 0281256 describes a centrifugation device for performing liposuction followed by lipoinjection. The centrifuge includes an air pump for suction and compression. In addition to the fact that this device requires numerous manipulations, it has been shown that during centrifugation, the extracted cells are subjected to very significant physical constraints, reducing their survival rate.
    The present invention aims to overcome all these drawbacks by proposing a space-saving device allowing a quick, simple and optimal treatment of fats, while
    -2 preserving the integrity of fat cells. The proposed device is also inexpensive and very profitable.
    Summary of the invention
    The present invention improves the technique by providing a mechanical device for the treatment of adipose tissue in a patient during an adipose tissue transfer procedure.
    It is an adipose tissue treatment device connected to a suction means, consisting of a sealed treatment chamber comprising a means of connection to said suction means, an input means of said adipose tissues before treatment. , a filtration means and at least one means for exiting said adipose tissues after treatment, said filtration means comprising an outer wall of conical shape comprising a constricted base fixed on a propeller and an inner sieving means connected to the outlet means, said propeller being subjected to the air vacuum created by the suction means and constituting a rotary mechanical actuation means of said filtration means.
    Preferably, the means of entry of said adipose tissues constitutes a means of entry of a cleaning fluid.
    Advantageously, the treatment chamber includes a means for leaving the cleaning fluid.
    According to one embodiment, the sieving means consists of a mesh, each of the meshes constituting the mesh having a dimension between 500 microns and 1 mm.
    According to a variant, the filtration means comprises at least one kneading means.
    Advantageously, the treatment chamber comprises an epicyclic train constituting a means of agitation of said adipose tissues.
    According to another embodiment, the treatment chamber is connected by means of connection to a means of electronic control of the process of treatment of adipose tissues.
    Preferably, the treatment chamber includes a fastening means.
    Brief description of the drawings
    In this description, reference is made to the appended drawings in which:
    - Figure 1: Shows a profile view of the device.
    - Figure 2: Shows a view of the installation and preparation of the device before the operation.
    - Figure 3: Shows a sectional view of the device.
    - Figure 4: Shows an exploded side view of the device.
    - Figure 5: Shows a sectional view of the intake block with a planetary gear train.
    -3- Figure 6: Represent a sectional view of the delivery block.
    - Figure 7: Shows a sectional view of the filter.
    Detailed description of preferred embodiments
    According to a preferred embodiment, the device is a mechanical and sealed treatment chamber (A), which transforms mechanical energy into energy of a different nature and thus ensures purification by centrifugation of the volume of adipose tissue. The operation of the treatment chamber (A) is based on the transformation of an air flow or flow into centrifugal force.
    The treatment chamber (A) designates all the parts serving or which can serve to control the process of treatment by centrifugation of the adipose tissue. This treatment chamber (A) has a central zone, an upper zone and a lower zone, these three zones are horizontal. To facilitate understanding of the device, the concept of technical block should be defined. A technical block is a solid mass forming a unitary body or a set of bodies integral with each other. Said blocks are composed of members such as grooves, shoulders, seats, housings, bores or the like, which simultaneously perform several functions such as allowing rotation or allowing the passage of a liquid, etc.
    Said treatment chamber (A) is composed of two stationary technical blocks called inlet block (1) and discharge block (2), linked by two screws (4,4 '). This treatment chamber (A) is also composed of a mobile technical unit called a filter (3).
    Said treatment chamber (A) provides most of the sealing by means of an envelope (5) bonded or thermally welded with the inlet and outlet blocks (1,2).
    Said intake block (1) located in the upper zone of the treatment chamber (A) has the main function of supplying the treatment chamber (A) with sufficient air and fatty tissue.
    Said inlet block (1) comprises a part outside the treatment chamber (A), and a part inside the treatment chamber (A), each part having a central zone, and a zone on each side, these last three zones are substantially vertical. Said inlet block (1) comprises, on its zone outside the treatment chamber (A), an inlet means called a conical inlet orifice (13) positioned in the center, which makes a fluid conduit (14) communicate with the 'outside. The intake unit (1) also includes on its outer part, two flat-bottom holes (15,15 ') for the passage and the tightening of the two cylindrical head screws (4,4').
    The intake unit (1) comprises, in its area inside the treatment chamber (A), a housing (16) in which the filter (3) is housed. Said inlet block (1) also includes, in its zone located inside the device, a vertical fluid duct (14), of cylindrical shape. Said vertical fluid conduit (14) routes the removed tissue (I) to be treated and a cleaning fluid (L) from the conical inlet (13) to the center of the filter (3). The block
    -4d'admitation (1) may include an opening with an antibacterial filter to allow more air to pass into the treatment chamber (A).
    The main purpose of the delivery block (2) located in the lower zone of said treatment chamber (A) is to discharge or evacuate the filtrate (F) and the adipose tissues (G) present in the treatment chamber (A) .
    Said delivery block (2) comprises a part outside the treatment chamber (A) and a part inside the treatment chamber (A), each part has a central zone, and a zone of each side, these last three zones are substantially vertical.
    Said delivery block (2) comprises, on its part external to the treatment chamber, a connection means called a conical outlet orifice (17) positioned in the center and which communicates a fluid conduit (18) with the outside. Said delivery block (2) also comprises on its outer part, a luer-lock outlet (19) for establishing a leak-free connection between an outlet means called fluid conduit (20) and a male syringe connector (K) .
    Said delivery block (2) comprises on its inner part said vertical fluid duct (18), which evacuates the air and the filtrate (F) present in the treatment chamber (A) towards the outside. The delivery block (2) also includes on its inner part said fluid conduit (20) which directs the fatty tissue (G) located in the filter (3) to the luerlock orifice (19). Said delivery block (2) further comprises four simple columns (21,21 ′, 21,2Γ) in the center, which support the intake block (1) and prevent the envelope (5) from being deformed under the effect depression and hinder the proper functioning of the device, then two columns (22,22 ') on the ends, linked to the intake block (1) through tapped holes (23,23') to the dimensions of the two screws (4.4 '). Said delivery block (2) also comprises on its inner part a housing (24) dimensioned to allow rotation of the propeller (25) of the filter (3). Said housing (24) is provided with a seat (26) which supports the filter (3). Said housing (24) is cylindrical in shape, it serves in particular as an inlet orifice for the filtrate (F) to a fluid conduit (18). The fluid conduit (18) extends from the housing (24) to the conical outlet (17). The dimensions of the duct (18) determine the general flow rate, therefore, the speed of rotation of the filter (3). Said cylindrical fluid duct (20) is at the center of the duct (18), it starts from an inlet orifice (27) in the center of the housing (24), up to the luer outlet orifice. lock (19). The inlet (27) guides the rotation of the filter (3).
    Said filter (3) located in the central zone of the treatment chamber (A), is a filtration means supported by the delivery block (2), is guided in rotation by the two blocks (1,2). Said filter (3) has the main function of centrifuging or separating the compounds of a mixture as a function of the differences in density of the solid particles suspended in a fluid, by subjecting them to a centrifugal force. Said filter (3) presents
    -5 a central zone, an upper zone and a lower zone, these three zones are horizontal.
    Said filter (3) has, on its upper zone, a ring (28) and a shoulder (29), designed to receive elements for measuring rotational speeds.
    Said filter (3) has in its central zone a screen (30), which traps the tissue (G) and discharges the filtrate (F). The confined volume of adipose tissue (G) inside the sieve (30), is otherwise called retentate (G). The conical shape of the interior sieving means (30) makes it possible to direct the adipose tissue (G) within it, and to benefit from at least 80% to 95% of the treated volume available. The screen (30) can be sized with a mesh ranging from 500 microns to 1mm. The screen (30) can be of any design, any porous structure. The screen (30) can be glued, welded, or molded to the filter (3) from a constricted base (55) to a ring (28). The retentate (G) available in the sieve (30) can be in a range having a lower limit of 50 cubic centimeters, and an upper limit of 350 cubic centimeters. Said screen (30) is stiffened by two conical reinforcements (31,31 ') which also support the ring (28) and form the wall of the filter (3). Said filter (3) also comprises two mixing means called mixers (32), which have the function of agitating the greases (G) during the rotation of the filter (3). The two mixers (32) are placed on the two reinforcements (31,3Γ). The two mixers (32) make it possible to improve the cleaning and the transfer of organic matter to the sieve (30).
    The filter (3) has on its lower zone, a rotary mechanical actuation means of said filtration means, a propeller (25) with four blades which transforms the energy of the suction flow into mechanical energy. The rotation of the propeller (25) about its axis is guided by the inlet orifice (27) of the delivery block (2). The number of blades can be varied to optimize the efficiency of the propeller (25). The propeller (25) consists of a minimum of two blades joined by the central part called the hub (33). The propeller torque (25) is related to the air flow. The tip of the blades has a higher linear speed than the more central blade sections. The mechanical energy produced by the propeller (25) depends on three parameters: the shape and length of the blades, the speed of the filtrate, and finally, the temperature which influences the density of the filtrate (F). The power of the propeller (25) depends mainly on the energy of the filtrate (F) and its variations. The mechanical energy of the propeller (25) is therefore an intermittent energy. In practice, the propeller (25) produces four times more energy if the blades are twice as large and eight times more energy if the suction rate doubles. The density of the filtrate (F) also comes into play, the propeller (25) produces 3% more power if, for the same speed, the filtrate (F) is colder by 10 ° C. The maximum power recoverable by the propeller (25) is given by Betz's law, which is equal to the product of the multiplication of atmospheric pressure with the swept area and the cube of the speed of the filtrate (F). Therefore, the atmospheric pressure, the surface swept, and the speed of the filtrate (F) are proportional to each other, and vary if one of them varies. The filter (3) comprises in the center of the hub (33) a fluid conduit (34) which collects by its
    -6 inlet port (35) the healthy tissue (G) in the screen (30) and leads it to the orifice (27) of the delivery block (2). The filter (3) has a shoulder (36), which aims to reduce the surface in contact with the seat (26), and thus reduce the friction during rotation of the filter (3). The filter (3) comes to rest on the seat (26) of said delivery block (2). The filter (3) can comprise weights, which are masses, in order to modify its balance or its inertia, in order to increase the speed.
    The envelope (5) which surrounds all of the technical blocks (1,2,3) forms the walls (38,38 ’) of the treatment chamber (A). Said envelope (5) provides most of the sealing of the treatment chamber (A). Said envelope (5) has a lower zone (interior or lower) and an upper zone, these two zones are horizontal.
    Said envelope (5) has on its upper attachment zone called handle (37) used to grip or carry the treatment chamber (A).
    Said envelope (5) has on its lower zone two walls (38,38 ') glued or thermally welded with the blocks (1,2). This envelope (5) can be made of flexible plastic, for example the same that can be found on the pockets of physiological liquid. The envelope (5) protects the adipose tissue (G) from external elements and more particularly from light rays, dust and micro-organisms or infectious agents.
    The envelope (5) can be of a material configured for low, medium, high depressions. Said envelope (5) can also be treated with anti-ultraviolet (UVA, UVB) and blue light. UV treatment is an essential criterion both to protect the adipose tissue (G) from the dangers of the sun and also to guarantee the adipose tissue (G) security against temperature variations.
    According to a variant, when the treatment chamber (A) comprises a large treatment volume, this presents a mechanism which agitates the volume of adipose tissue (G) by moving it, from the bottom to the top, and around the axis (a) of rotation of the filter (3). This means of agitation of said adipose tissue is otherwise called epicyclic gear train (6). A gear train is called a planetary gear when it has the particularity of having two degrees of mobility. During operation, the gear wheels or pinions that make up the train do not all rotate around fixed axes, which gives them a planetary travel, hence the name given to the train (6). Said epicyclic gear train (6), located in the upper zone of the treatment chamber (A), is housed in the housing (16) of said intake block (1). Made up of gears, this epicyclic gear train (6) has an inner planetary area, an outer planetary area, and a satellite area between the two previous areas, these three areas are coaxial. Said planetary gear (6) comprises two so-called planetary coaxial shafts (8,9), and three satellites (7,7 ', 7) meshing with the two planetary (8,9). Said inner planetary (8) is sometimes called the sun, and the outer planetary (9) called the crown. In this version, said train
    - 7 of planetary gears (6) of said treatment chamber (A) is composed in addition of a planet carrier (10), and a pin (11). In addition, the ring (28) of the rotary filter (3) integrates an internal gear ring (9), and the duct (14) of the intake block (1) integrates a flat (39), a shoulder (40 ), and a bore (41). The mechanism is housed in the housing (16) of the intake block (1), between said shoulder (40) of the intake block (1) and said pin (11) housed in the bore (41) of the fluid conduit ( 14).
    Said ring (9) of the filter (3) located in the outer planetary zone of said train (6) of the treatment chamber (A), distributes the power to the various agitators (7, 7 ', 7) in a balanced manner.
    Said epicyclic agitators (7,7 ', 7), located in the satellite zone of said train (6) of the treatment chamber (A), each have a central zone, an upper zone and a lower zone, these three zones are horizontal . These three epicyclic agitators (7,7 ', 7), are of equivalent dimensions and appearance, but can have different configurations. The epicyclic agitators (7,7 ', 7), mix the fatty tissue (G) mainly with two movements, from the periphery to the center and vice versa, and / or, from the bottom to the top.
    Said agitators (7,7 ', 7) are each composed of a shaft (42) in their upper zones in pivot connection with the satellite carrier (10). Each shaft (42) receives an elastic ring (12,12 ', 12). Said elastic rings otherwise called circlips (12,12 ', 12'j are provided to hold the shafts (42) in position.
    Said agitators (7,7 ', 7), are composed on their central zones of three pinions (43) with straight teeth. The paths of the points of the pinions (43) relative to the input block (1) are cycloidal curves, hence the name given to the device. The teeth of the pinions (43) are in contact with the teeth of the two planets (8, 9). Said agitators (7,7 ', 7) agitate the fabric (G) at a lower speed than that of the kneaders (32) of the filter (3). Said agitators (7, 7 ', 7), are each composed on their internal zones of a whisk (44), for mixing or agitating the retentate (G) composed of the tissue removed (I), of physiological liquid (L), and air. During operation of the device, said whips (44) agitate the tissue (G) along a trajectory around the axis (b), and a trajectory around the axes (c, c ', c'j. Said epicyclic agitators (7 , 7 ', 7), rotate around their axes (c, c', c'j in movement relative to the axis (b) of the duct (14). Said agitators (7,7 ', 7) rotate on a fixed wheel (8) at the large intake block (1) ensuring a silent and precise rotation, even in difficult working conditions. Said fixed wheel (8) supports the satellite carrier (10). of the fixed wheel (8) is stopped by the flat (39), its vertical position is determined by the pin (11) in the bore (41).
    Said agitators (7,7 ', 7), are composed on their lower zones of three whips (44). Said whips (44) are in contact with the adipose tissue (G), said whips (44) have the function of agitating and separating the components of the retentate (G). The shape of the whisk (44) can be modified to allow better treatment of fat (G).
    -8 Said satellite carrier (10) is housed between the shoulder (40) of the intake unit (1) and the fixed wheel (8). Said satellite carrier (10) functions as a crank rotating about the axis (b) and the conduit (14). Said satellite carrier (10) has three cranks (10 ') equidistant from 120 degrees. Each crank (10 ') includes a housing where the agitators (7,7', 7) are housed. Said cranks (W) transform into a rotational movement around the axis (b), one or more forces transmitted by the agitators (7,7 ', 7).
    Said pin (11) and its bore (41) are intended to define the horizontal positions of the fixed wheel (8) and the satellite carrier (10), and therefore, the positions of the agitators (7,7 ', 7) , while ensuring the proper functioning of the planetary gear train (6). Said pin (11) and its bore (41) allow a compromise between the precision required for satisfactory operation of said planetary gear (6), and the technical and economic constraints of manufacturing.
    Said conduit (14) of the intake block (1) integrates a flat (39). Said flat (39), also called flat, is a flat surface on the fluid conduit (14) of cylindrical shape. This flat (39) hinders the movement of the fixed wheel (8), in order to deliberately block its rotation.
    Too much or too dry adipose tissue (G) can cause suffocation, lethal ischemia of fat cells (G), which can lead to poor results, inconvenience and even health risks. Therefore controlling the process during treatment can be vital for fat fat cells (G).
    According to another variant, said treatment chamber (A) then presents a set of hardware, software and modifications in the treatment chamber (A) used to monitor or control the process of treatment of adipose tissue (G). According to this preferred embodiment, said treatment chamber (A) can have the integration of electronic components (45,45 ', 46,46'), as well as a certain number of modifications to the intake block (1) relating to these electronic components. According to this preferred embodiment, said processing chamber (A) can additionally have a monitor (47) displaying humidity and temperature levels recorded by the electronic components (45,45 (46,46 ') of said chamber processing (A), so that the user can check the condition of the cells (G).
    According to this preferred embodiment, said process control is ensured in the treatment chamber (A), by at least one active electronic component called a sensor (45) allowing the humidity and temperature measurements. To facilitate the description, a single sensor is shown. However, the processing chamber (A) can be equipped with speed, temperature, humidity and light sensors, jointly and / or independently. Said sensor (45) collects the humidity and temperature values of the adipocytes (G) without altering their qualities, and transmits them by its electronic circuit (45 '). Said electronic circuit (45 ') transmits the data revealed by said sensor (45) by means of connection called USB port (46) by the connector (46').
    According to this preferred embodiment, the intake unit (1) comprises on its external part, a base (48) for electronic control means called monitor (47), as well as a housing (49) for the USB port. (46) 2.0 or 3.0 male. In said version, the intake block (1) has on its inner part, a fluid conduit (14) with reduced dimensions to make room for an electronic conduit (50). Said electronic conduit (50) runs along the fluid conduit (14) of the housing (49) to the center of the filter (3). Said electronic conduit (50) allows passage and housing of the electronic circuit (45 ') of the sensor (45). The electronic conduit (50) also makes it possible to avoid any risk of short circuit. Said whips (44) can also be declined as required, they can both include a temperature sensor, a humidity, light sensor, or remain simple.
    According to this preferred embodiment, said monitor (47) allows the communication of the device with the user. Said monitor (47) is composed of a TFT or LCD screen (51) which displays the result of a measurement. The display can be analog, either with the particularity of having a system of temperature or humidity indicators which is done by means of the movement of a hand on a dial, or digital, or with the indications directly in the form of numbers or letters. A backlight can be integrated into the screen (51).
    The monitor (47) incorporates a programmable micro or nano card (52) which has an easily programmable microcontroller, as well as numerous input-outputs. It is useful to specify that several cards exist, they are differentiated by the power of the microcontroller or by the size and the consumption of the card. The choice of the type of card is made according to the needs. The card (52) is programmed using free programming software.
    The monitor (47) incorporates a lithium-ion battery (53), with a rigid shell or sheath. Said lithium-ion battery (53) provides significant autonomy with a limited volume and weight. Said battery (53) is with a protection circuit and does not require any external protection against overcharging, reverse polarity or a possible charger fault. In addition, the monitor (47) can be directly supplied by a charger whose voltage is between 7 and 12 volts.
    The monitor (47) incorporates a dressing solution with a shell (54) and a cover (54 '). The shapes of said shell (54) and cover (54 ') can be modified if necessary. Said shell (54) and cover (54 ') provide protection against humidity or simply protection against impacts.
    The monitor (47) can also contain light measurement probes, sound warning or lighting systems if necessary.
    It is important to note that in this version of the device, the electronic components (45,45 ', 46) in the processing chamber (A) depend energetically on the monitor (47). The monitor (47) can communicate with the processing chamber (A) by wired connection (USB, jack, optical fiber, etc.). However, other designs may
    -10 allow the treatment chamber (A) to be energy independent. According to one variant, the treatment chamber (A) has a dynamoelectric function linked to the rotation of the filter (3), or according to another variant the treatment chamber (A) has a motor and a battery, etc. Thus the processing chamber (A) can transmit the graphic values to a computer, a printer, a smart phone, or a touch pad, by wireless transmission (Bluetooth, Wifi, SMS, email, etc.).
    It should be added that a certain number of improvements, of additional individual functionalities, or in combination are applicable to the invention.
    Each of the elements can, without being required to, be used with any other characteristic or combination. The device can be made of any suitable building material; each piece, component; or together, may consist of one or more plastic compositions. The device can be configured with a very practical size for optimal use of the collection volume. The device is designed for a number of uses defined by the state of the filter (3). The device can be sized for transport (moved to other different locations where a variety of processing of the collected tissue can be performed). The device can be packaged in a sterile and hermetic environment, in a packaging for transport or storage in a tissue bank before use. The device can be sterilized before by dry heat, saturated steam, or after packaging by exposure to plasma. To prevent risks associated with misuse, it can be cut with a scissor, to damage the device in a way that makes it unsatisfactory for reuse.
    The device can be portable and easily transportable between locations where different collection or processing operations can be carried out.
    To use the device, the user needs:
    - an operating theater or room (B)
    - of a patient (P) represented in the figures by a mannequin on an operating table (Q).
    - a means or suction system (M) with a collection system (N).
    - an infusion stand otherwise known as a gallows (O).
    - a pocket of physiological liquid (L),
    - a cannula (R) to allow aspiration without damaging the tissues.
    - T-shaped three-way valve (D)
    - four surgical hoses (C, J, E, H, S), with conical connection.
    - a syringe (K) with luer-lock connection.
    Said operating room or block (B) is designed to optimize patient safety and to contribute to infection prevention procedures. The operating rooms generally benefit from the latest generation of equipment. These rooms benefit from high-performance and modular medical devices, suitable for performing complex surgical procedures but also to facilitate university teaching.
    -11 The patient (P) is prepared for ambulatory surgery, or more simply, programmed surgery carried out under technical conditions imperatively requiring the safety of an operating theater, under variable mode anesthesia, followed by postoperative monitoring allowing, without increased risk, the patient's discharge the same day of his intervention. Said surgical procedure is identical to that performed in conventional surgery with full hospitalization. There is also no specificity for anesthesia. It is not the act that is ambulatory, but the patient.
    The operation of the treatment chamber (A) is based on the air flow and the centrifugal force. Therefore, the treatment chamber (A) works with any type of suction means. However, ideally, and for ease of understanding, said suction means is a technical platform (M) allowing the connection to medical fluid sockets, electrical sockets, and Ethernet sockets, of equipment in the operating rooms and intensive care. Said technical platform (M) is integrated into the operating room (B). The technical platforms can be configured as required. Thus any additional accessory can be added to the technical platform (M) such as electrical outlets, gas outlets, nurse calls, light switches etc. Said technical platform (M) is fluidly connected with the collection (N) by a pipe (S).
    Said infusion stand (O) otherwise called a gallows is a mobile element where one hangs a pocket or the infusion bottle, to allow the patient to move. Said infusion stand (O) is either on casters for increased mobility or fixed on the bed for a minimum of space.
    The physiological liquid (L) is generally composed of distilled water and sodium chloride, and is harmless for the body, it is commonly used for medical purposes in particular for the vascular filling in intravenous infusion, the cleaning of wounds, or the temporary maintenance of organs separated from the body in a state conducive to observation, analysis or transplantation. Physiological fluid (L) is incorrectly named physiological saline but does not come directly from the blood.
    The treatment chamber (A) works with different methods of sampling from a patient, or with tissue conditioned by a tissue bank. Therefore, a small tube or pipe allowing the passage of tissue and liquid through an orifice obtained after surgical intervention on the patient (P), or is sufficient for the proper functioning of the treatment chamber (A). However, and for ease of understanding, the use of a collection cannula (R) is used in the procedures for transferring collected tissue (I), during the phase of removal of adipose tissue (G) within the body. of the patient (P). Said cannula (R) does not have projecting angles or edges and does not leave pressure points.
    Said 3-way valve (D) is with 2 injection sites, each with an operating lever (D ', D). The first lever (D ') controls the flow of the aspirated sample, and the second lever (D) controls the flow of physiological fluid. Said tap (D) can be
    -12 automated, by means of a servomotor or ensuring the conversion of a control signal into movement of the operating levers (D ', D). According to another embodiment where the tissue sample (I) and the physiological fluid (L) only mix in the treatment chamber (A), said 3-way valve (D) is replaced either by two orifices (13) for the fluid duct (14) of the intake block (1), or by a second fluid duct identical to the fluid duct (14).
    Said surgical hoses (C, J, E, H, S) keep their shapes perfectly during aspiration. Each end has universal female connectors for convenient and secure attachment. Two pipes (C, J) respectively serve to fluidly connect the treatment chamber (A) with the outlet of the tap (D) and the collection (N) of the technical platform (M), as well as two pipes (E, H) which respectively serve to fluidly connect the tap inputs (D) with the physiological liquid (L) and the suction cannula (R).
    For the preparation, the following steps should be observed: install the treatment chamber (A) by its handle (37) on the stem (O). Install the physiological saline (L) on the stem (O). Connect a first pipe (C) to the inlet port (13). Connect the pipe (J) from the collection (N) to the filtrate outlet (17) of the treatment chamber (A). Connect the luer-lock syringe (K) to the luer-lock outlet (19) of the treatment chamber (A). Check that the levers (D ') and (D) of the tap (D) are closed. Connect the hose (C) to the valve outlet (D). Connect the physiological saline (L) to a first inlet port of the tap (D), using the pipe (E). Connect the hose (H) of the suction cannula to a second inlet port of the tap (D). Install the monitor (47) on the base (48). Switch on the monitor (47). Activate the suction.
    The treatment chamber (A) can include a mechanical function of on / off of the centrifugation of the filter (3) located outside.
    The complete opening of the lever (D ') of the tap (D) allows the user to sweep with the cannula (R) the area where the tissue (I) is to be removed, and allows to mechanically activate the treatment chamber (AT). Under the effect of the suction flow, the removed tissue (I) is sucked away through the pipe (H) to the tap (D). Under the effect of the suction flow the propeller (25) is activated and transforms the energy of the suction flow into mechanical energy, in rotational movement. Then begins the centrifugation phase.
    The partial opening of the lever (D) of the tap (D) allows the physiological liquid (L) to flow along the pipe (E), under the effect of gravity and depression, to the tap (D ). The partial opening of the lever (D) also makes it possible to control the flow of physiological fluid (L). The removed tissue (I) and the physiological liquid (L) mix in the tap (D) to exit into the pipe (C). The pipe (C) directs the physiological liquid mixture (L) / sampled tissue (I) towards the orifice (13) of the treatment chamber (A). The physiological liquid mixture (L) / sampled tissue (I) crosses the conduit (14), then is deposited in the screen (30) of the filter (3). The filter (3) using mixers (32) agitates the mixture
    - 13 physiological liquid (L) / tissue removed (I) and retains only fat or adipose tissue (G). In addition, the physiological saline (L), both hydrophilic and hydrophobic, fixes itself on the organic matters that water alone cannot remove and evacuates them through the sieve (30) under the effect of inertia. The screen (30) confines a retentate (G), and releases the cleaning fluids (L) and materials of smaller sizes. When the treatment chamber (A) comprises an epicyclic train (6), the agitators (7,7 ', 7) agitate the adipose tissue (G) inside the filter (3). This improves its treatment and rinsing. The mixture discharged through the mesh of the sieve (30) is called the filtrate (F). The filtrate (F) is carried from the outside of the screen (30), to the fluid conduit (18) of said delivery block (2), then discharged through the outlet orifice (17) into the pipe (J) up to the collection (N) of the technical platform (M).
    Under the effect of gravity the filtrate (F) falls into the conduit (18). The filtrate (F) is then continuously discharged. As it travels, the filtrate (F) transmits all of the forces to the propeller (25), which reduces the torque and increases the nominal speed of rotation of the filter (3). The filtrate (F) is directed along the duct (18) towards the orifice (17), to join the pipe (J). The filtrate (F) is directed along the conduit (18) under the effect of gravity and depression.
    A small volume of adipose tissue (Gj is directed along the conduit (20), this volume is little or not treated, so it must be removed and discarded.
    Once the required volume of tissue (G) has been reached, leave the levers (Dj and (D) of the tap (D) open, until the filtrate (F) is mainly composed of physiological saline (L). inlet block (1) can include an opening with an anti-bacterial filter to increase the flow in the treatment chamber (A) and the speed of the filter (3) When the filtrate (F) is mainly composed of serum physiological (L), close the lever (D). In said version or the device includes a monitor (47), check the humidity and the temperature recorded by the sensor (45) on the monitor (47). During the processing of adipose tissue (G), the user can monitor the state of the adipose tissue (G) on the monitor (47).
    To the satisfaction of the condition, close the lever (D ') of the tap (D). Stop the suction system. Aspirate the volume of untreated tissue (G ') housed in the conduit (20), using the syringe (k). Empty the contents of the syringe (K) into a suitable container. Insert the syringe (k) into the luer-lock port and extract the retentate (G) contained in the treatment chamber (A), in order to graft it. The conical shape of the filter (3) makes it possible to direct the tissue (G) within it, and to benefit from 80% to 95% of the treated volume available. The use of a treatment chamber (A) is from one donor to several recipients. As a result, the user can take several tissue samples from one donor, and re-transplant them from different recipients.
    After use, the device can be put to waste or selective sorting as appropriate.
    Many variants which may possibly be combined can be brought here without ever departing from the scope of the invention as defined above.
    Insubstantial changes that would obviously result, for humans
    - 14de art, use or manufacture whose patent is required here without altering the original provisions, would be mere technical equivalents and also fall within the scope of the present invention.
    Industrial applications
    The device can be used for a variety of treatment applications involving fatty tissue.
    The device can be used for various applications such as lipofilling, breast reconstruction and reconstruction, scar filling, etc.
    The device can be used for the treatment before analysis of adipose tissue and can allow the execution of several different operations when it is in operation.
    The device can be used for the preparation of concentrates, or in order to separate the parts of the sampled tissue.
    权利要求:
    Claims (9)
    [1" id="c-fr-0001]
    1. Device for processing adipose tissue (G) connected to a suction means (M) characterized in that it consists of a mechanical and sealed treatment chamber (A), comprising a connection means (17) to said suction means (M), an inlet means (13) of said adipose tissues (G) before treatment, a filtration means (3) and at least one outlet means (20) of said adipose tissues (G) after treatment, said filtration means (3) comprising at least one wall of conical shape (31, 31 j comprising a constricted base (55) fixed on a propeller (25) and a screening means (30) connected to the outlet means ( 20), said propeller (25) being subjected to the vacuum of air created by the suction means (M) and constituting a rotary mechanical actuation means of said filtration means (3).
    [2" id="c-fr-0002]
    2- Device for treating adipose tissue (G) according to claim 1 characterized in that the inlet means (13) of said adipose tissues (G) constitutes a means for entering a cleaning fluid (L).
    [3" id="c-fr-0003]
    3- Device for treating adipose tissue (G) according to claim 2 characterized in that the treatment chamber (A) comprises a means for leaving the cleaning fluid (L) and materials of sizes smaller than the mesh size of the sieving means ( 30).
    [4" id="c-fr-0004]
    4- Device for processing adipose tissue (G) according to claim 1 characterized in that the sieving means (30) consists of a mesh, each of the meshes constituting said mesh having a dimension between 500 microns and 1 mm.
    [5" id="c-fr-0005]
    5- adipose tissue treatment device (G) according to claim 1 characterized in that the filtration means (3) comprises at least one kneading means (32).
    [6" id="c-fr-0006]
    6- Device for treating adipose tissues (G) according to one of the preceding claims, characterized in that the treatment chamber (A) may comprise an epicyclic train (6) constituting a means of agitation of said adipose tissues (G).
    [7" id="c-fr-0007]
    7- Device for treating adipose tissue (G) according to one of the preceding claims, characterized in that the treatment chamber (A) may comprise at least one active electronic component (45) connected by means of connection to a means of electronic control (47) of the adipose tissue treatment process (G).
    [8" id="c-fr-0008]
    8- Device for treating adipose tissue (G) according to one of the preceding claims, characterized in that the treatment chamber (A) is delimited by a flexible material (5) protecting the adipose tissue (G) from the external elements.
    [9" id="c-fr-0009]
    9- Adipose tissue treatment device (G) according to one of the preceding claims, characterized in that the treatment chamber (A) comprises a fastening means (37).
    plate 2/7
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    同族专利:
    公开号 | 公开日
    CA3059665A1|2018-10-18|
    BR112019021313A2|2020-05-19|
    KR20190134740A|2019-12-04|
    EP3609550B1|2021-06-09|
    EP3954403A1|2022-02-16|
    FR3056405B1|2019-11-01|
    EP3609550A1|2020-02-19|
    CN110678211A|2020-01-10|
    WO2018189431A1|2018-10-18|
    US20200061259A1|2020-02-27|
    ES2886196T3|2021-12-16|
    PT3609550T|2021-07-20|
    引用文献:
    公开号 | 申请日 | 公开日 | 申请人 | 专利标题
    US20120271254A1|2011-02-22|2012-10-25|Schafer Mark E|Canister for autologous fat transfer|
    WO2014039697A1|2012-09-06|2014-03-13|The Gid Group, Inc.|Tissue processing apparatus and method for processing adipose tissue|WO2020235986A1|2019-05-17|2020-11-26|Roblero Rivera Carlos Alexander|Filter for collecting, processing and injecting a graft of fatty tissue|KR200355004Y1|2004-04-19|2004-07-01|메디칸|Centrifuge Functioning as Liposuction and Lipoinjection|
    US20140081237A1|2012-09-20|2014-03-20|Tissue Genesis, Inc.|Hand-held micro-liposuction adipose harvester, processor, and cell concentrator|US11033295B2|2019-05-06|2021-06-15|Tissuemill Technologies Llc|Atraumatically formed tissue composition, devices and methods of preparation and treatment|
    CN110935072B|2019-12-03|2022-02-08|上海交通大学医学院附属第九人民医院|Device for integrally treating adipose tissues and treatment method thereof|
    GB2587257B|2020-03-09|2021-09-15|Alma Lasers Ltd|Lipoaspirate processing|
    法律状态:
    2018-02-05| PLFP| Fee payment|Year of fee payment: 2 |
    2018-03-30| PLSC| Publication of the preliminary search report|Effective date: 20180330 |
    2019-04-09| PLFP| Fee payment|Year of fee payment: 3 |
    2019-10-04| TP| Transmission of property|Owner name: GARONA-ESTUDI, FR Effective date: 20190825 |
    2020-04-29| PLFP| Fee payment|Year of fee payment: 4 |
    2020-06-19| PLFP| Fee payment|Year of fee payment: 5 |
    2021-04-23| PLFP| Fee payment|Year of fee payment: 5 |
    优先权:
    申请号 | 申请日 | 专利标题
    FR1770365|2017-04-11|
    FR1770365A|FR3056405B1|2017-04-11|2017-04-11|DEVICE FOR TREATING GREAT CELLS FROM A PATIENT AND INTENDED FOR GRAFT.|FR1770365A| FR3056405B1|2017-04-11|2017-04-11|DEVICE FOR TREATING GREAT CELLS FROM A PATIENT AND INTENDED FOR GRAFT.|
    EP18727042.6A| EP3609550B1|2017-04-11|2018-04-06|Device for treating fat cells taken from a patient and intended for a transplant|
    KR1020197032713A| KR20190134740A|2017-04-11|2018-04-06|Device for processing transplanted fat cells taken from the patient|
    US16/604,307| US20200061259A1|2017-04-11|2018-04-06|Device for treating fat cells taken from a patient and intended for a transplant|
    CA3059665A| CA3059665A1|2017-04-11|2018-04-06|Device for processing fat cells taken from a patient and intended for a transplant|
    PCT/FR2018/000076| WO2018189431A1|2017-04-11|2018-04-06|Device for treating fat cells taken from a patient and intended for a transplant|
    PT187270426T| PT3609550T|2017-04-11|2018-04-06|Device for treating fat cells taken from a patient and intended for a transplant|
    CN201880028108.8A| CN110678211A|2017-04-11|2018-04-06|Device for processing adipocytes removed from a patient and used for transplantation|
    EP21184172.1A| EP3954403A1|2017-04-11|2018-04-06|Device for treating fat cells taken from a patient and intended for a graft|
    BR112019021313A| BR112019021313A2|2017-04-11|2018-04-06|device to treat fat cells taken from a patient and destined for a transplant|
    ES18727042T| ES2886196T3|2017-04-11|2018-04-06|Device for the treatment of fat cells extracted from a patient and destined for transplantation|
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